Prurigo nodularis is a challenging problem to treat. It manifests as nodules in the skin, secondary to chronic scratching, and underlying pruritus (itch). Prurigo nodularis has been treated with a wide range of medications and treatments, including topical steroids, antihistamines, mirtazapine, gabapentin, phototherapy, and cyclosporine with variable results. Two recent case study reports indicate that… Read More
Serlopitant For Prurigo Nodularis Completes Phase 2 Clinical Trial
A new treatment for prurigo nodularis is coming down the drug development pipeline. Prurigo nodularis is marked by persistent itching, stinging and burning sensation in the skin, resulting in a chronic itch-scratch cycle and resulting nodules where the skin is picked and scratched. In a phase 2 clinical trial, serlopitant, a neurokinin-1 receptor antagonist that… Read More
Prurigo Nodularis – A Frustrating Problem
Prurigo nodularis (PN) describes a skin condition with firm itchy nodules, in which the skin changes are thought to be secondary to the repetitive trauma of scratching. The lesions can be skin-colored, brown, or red, sometimes with scale, crust, or erosion and ulceration. Lesions of prurigo nodularis are typically on the extensor aspects of the… Read More
