In recent years, there has been a growing interest in the potential applications of naltrexone in dermatology. Naltrexone, primarily known for its role in addiction treatment, has shown promise as an effective tool in managing various skin conditions. This post explores the use of naltrexone in dermatology, shedding light on its mechanisms, benefits, and potential therapeutic applications.

Understanding Naltrexone

Naltrexone is an opioid receptor antagonist, meaning it blocks the actions of opioid compounds in the body. Traditionally, it has been used to treat substance use disorders by reducing the pleasurable effects of opioids. However, researchers have uncovered its additional properties that make it valuable in the field of dermatology.

Mechanisms of Action of Naltrexone

Naltrexone’s effectiveness in dermatology is linked to its influence on the immune system. This medication can modulate the immune response and reduce inflammation, making it a potential option for managing several dermatological conditions.

Naltrexone’s Applications in Dermatology

Lichen Planopilaris (LPP)

Naltrexone has shown promise in treating LPP, an inflammatory condition that affects hair follicles. It can help reduce inflammation and slow down the progression of the disease.

Prurigo Nodularis

For patients suffering from prurigo nodularis, a condition characterized by intensely itchy nodules, naltrexone may provide relief by reducing the itching sensation and inflammation.


Preliminary studies suggest that naltrexone may have potential in managing psoriasis, a chronic autoimmune skin condition. It can help in suppressing the overactive immune response responsible for psoriatic lesions.

Hidradenitis Suppurativa

Naltrexone’s anti-inflammatory properties can benefit individuals with hidradenitis suppurativa, a chronic skin condition marked by painful abscesses and boils.

Chronic Urticaria

Chronic urticaria, a skin condition characterized by hives, may also respond positively to naltrexone treatment. It can help reduce the frequency and severity of hives.


Recent research and clinical experience have indicated that naltrexone may be a promising treatment for Hailey-Hailey disease.

Dosage and Safety

The appropriate dosage of naltrexone for dermatological conditions can vary depending on the specific condition and the patient. Dermatologists will typically prescribe lower doses than those used in addiction treatment, which minimizes the risk of side effects.


While more research is needed to fully understand the extent of naltrexone’s potential in dermatology, the preliminary results are promising. This medication offers a new avenue of treatment for various dermatological conditions by targeting the underlying inflammation and immune responses. If you have a skin condition that has been difficult to manage with traditional treatments, discussing the possibility of naltrexone therapy with your dermatologist may be a valuable step toward finding relief.

Call 973-763-7546 to schedule a dermatology consultation today.


Back to all Posts