Naltrexone in Dermatology

In recent years, there has been a growing interest in the potential applications of naltrexone in dermatology. Naltrexone, primarily known for its role in addiction treatment, has shown promise as an effective tool in managing various skin conditions. This post explores the use of naltrexone in dermatology, shedding light on its mechanisms, benefits, and potential… Read More

Dupilumab (Dupixent) For Prurigo Nodularis

Prurigo nodularis is a challenging problem to treat. It manifests as nodules in the skin, secondary to chronic scratching, and underlying pruritus (itch). Prurigo nodularis has been treated with a wide range of medications and treatments, including topical steroids, antihistamines, mirtazapine, gabapentin, phototherapy, and cyclosporine with variable results. Two recent case study reports indicate that… Read More

Serlopitant For Prurigo Nodularis Completes Phase 2 Clinical Trial

A new treatment for prurigo nodularis  is coming down the drug development pipeline. Prurigo nodularis is marked by persistent itching, stinging and burning sensation in the skin, resulting in a chronic itch-scratch cycle and resulting nodules where the skin is picked and scratched. In a phase 2 clinical trial, serlopitant, a neurokinin-1 receptor antagonist that… Read More

Prurigo Nodularis – A Frustrating Problem

Prurigo nodularis (PN) describes a skin condition with firm itchy nodules, in which the skin changes are thought to be secondary to the repetitive trauma of scratching. The lesions can be skin-colored, brown, or red, sometimes with scale, crust, or erosion and ulceration. Lesions of prurigo nodularis are typically on the extensor aspects of the… Read More