What is Seysara For Acne?

Seysara (sarecycline) is the newest (approved in 2018) antibiotic for the treatment of acne vulgaris in patient ages 9 and up. It is in the tetracycline class, and related to the well-known acne medications doxycycline and minocycline.

What is the dosing for Seysara?

Seysara is dosed by weight.

  • 60 mg for patients who weigh 33-54 kg
  • 100 mg for patients who weigh 55-84 kg
  • 150 mg for patients who weigh 85-136 kg

What are side-effects for Seysara?

The side-effects for Seysara are similar to other tetracycline class medications, including: nauseau, light-headedness, dizzyness, and sun sensitivity. See Seysara full prescribing information for full details.

How effective is Seysara in treating acne?

The safety and efficacy of once daily Seysara was assessed in two 12-week multicenter, randomized, double-blind, placebo-controlled studies. The two efficacy endpoints were percentage of subjects with Investigator’s Global Assessment (IGA) success: a score of clear (0) or almost clear (1) and 2-point decrease from baseline on IGA score at Week 12; and absolute reduction from baseline in inflammatory lesion counts at Week 12.

On the IGA endpoint in the two studies, 21.9% and 22.6% had IGA success versus 10.5% and 15.3% for placebo, respectively. On the second endpoint of absolute lesion reduction, the results showed 15.3 and 15.5 lesion reduction for Seysara versus 10.2 and 11.1 with placebo, respectively. This is a percentage reduction of 52.2% and 50.8% versus 35.2 and 36.4%, respectively.

Is Seysara better than Minocycline or Doxycycline?

There is no head-to-head study to suggest that Seysara is better than minocycline or doxycycline in treating acne.

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