Periorificial Dermatitis

Periorificial dermatitis is a common inflammatory skin condition that typically affects the area around the mouth, nose, and eyes. At SOMA Skin & Laser, our board-certified dermatologists offer expert diagnosis and tailored treatment plans to manage and resolve this often stubborn condition.

What Is Periorificial Dermatitis?

Periorificial dermatitis (also called perioral dermatitis when it’s localized to the mouth) presents as red, inflamed bumps and patches of irritated skin. The rash can resemble acne or rosacea but typically spares the skin immediately adjacent to the lips. In some cases, mild scaling or burning may be present.

This condition most frequently affects:

  • Women aged 20–45

  • Children (often around the nose and eyes)

  • Individuals using topical steroids

Common Triggers

The exact cause of periorificial dermatitis is unknown, but several triggers have been identified:

  • Topical corticosteroids (including over-the-counter hydrocortisone)

  • Inhaled corticosteroids (especially if used without a spacer)

  • Cosmetics and moisturizers

  • Fluoridated toothpaste

  • Hormonal changes

  • Microbial imbalance or overgrowth (e.g., fusiform bacteria or candida)

Symptoms

  • Red, bumpy rash around the mouth, nose, or eyes

  • Mild burning or itching

  • Flaky or scaly skin

  • Absence of comedones (blackheads or whiteheads), distinguishing it from acne

Diagnosis

Our dermatologists diagnose periorificial dermatitis based on a thorough skin exam and medical history. In some cases, a culture or skin scraping may be performed to rule out infection or other inflammatory conditions.

Treatment at SOMA Skin & Laser

We offer a customized, stepwise approach to treatment, which may include:

Discontinuation of Topical Steroids

Stopping all corticosteroid creams is often the most important first step—even if the rash initially flares after stopping.

Topical Medications

  • Metronidazole

  • Azelaic acid

  • Clindamycin

  • Sulfur-based creams

  • Calcineurin inhibitors (e.g., tacrolimus or pimecrolimus)

Oral Medications

For more severe or persistent cases:

  • Tetracycline-class antibiotics (e.g., doxycycline or minocycline)

  • Erythromycin (for children or pregnant women)

Skincare Guidance

We provide recommendations on:

  • Gentle cleansers and moisturizers

  • Avoidance of heavy makeup or occlusive products

  • Switching to fluoride-free toothpaste when appropriate

Why Choose SOMA Skin & Laser?

Our dermatology experts understand the frustration and sensitivity of facial rashes like periorificial dermatitis. At SOMA Skin & Laser, we combine clinical expertise with patient-centered care to help you achieve clear, healthy skin.

  • Board-certified dermatologists

  • On-site treatments and tailored skincare plans

  • Pediatric and adult dermatology

  • Convenient locations in New Jersey

Schedule a Consultation

If you’re struggling with a persistent facial rash, let us help.
Call us at (973) 763-7546 to schedule your evaluation.

**Results may vary patient to patient. There is no guarantee that any specific result can be achieved.
Request More Information